Henderson will mark Messi. PROBLEM SOLVED.
Edit: Seriously, I think coming into the season, the basic expectation for this squad was to get out of its group. When they drew Porto, that expectation was raised to making the quarterfinals. By reasonable measures, advancing to the semifinals would be a fantastic overachievement for this squad.
I think they can with the right match up and some excellent defending, the right match up being any of the EPL sides, Roma/Shakhtar, or Sevilla. Maybe Juve, but think the defense would really struggle with the Higuain-Dybala combo. Bayern, Barca, & Real still seem a cut above at this point.