I'm with Ras--the Sox can't (and I don't think they will) overreact and deal some of the untouchable prospects to get saddled with Hamels. I do trust the FO to have numerous plans--it's what they do for a living as opposed to those of us on here squeezing in the GM thing in between our real jobs. There is enough pitching available that the team can fill out a decent rotation with the kids getting good looks by the organization. With the projected lineup, the Sox will score runs and we'll see how the pitching goes.
As far as Lester goes, I think he's gone, either to the Cubs or SF. I'd like to be wrong, but the way this has played out I think the Lester team is holding out for top dollar. If I recall correctly, the Levinson brothers also represented Pedroia, and they made some comments after the Pedroia extension that made it pretty clear they didn't like the idea that he left a considerable amount of money on the table, (which is understandable from their perspective) so maybe they are driving a much harder negotiation this time around. Anyway, paying Lester in excess of $150 million for 7 years is not a good option IMHO.