Patrick Mahomes is an absolute beast. His overall stats this year are off the charts, and obviously they're great at home. Here are his 9 home games (including playoffs):
vs SF: 24-38, 326 yds, 6 td, 0 int, 154.8 rating
vs Jax: 22-38, 313 yds, 0 td, 2 int, 62.7 rating
vs Cin: 28-39, 358 yds, 4 td, 1 int, 123.7 rating
vs Den: 24-34, 303 yds, 3 td, 1 int, 125.0 rating
vs Ari: 21-28, 249 yds, 2 td, 0 int, 125.4 rating
vs Bal: 35-53, 377 yds, 2 td, 1 int, 91.5 rating
vs LAC: 24-34, 243 yds, 2 td, 0 int, 110.3 rating
vs Oak: 14-24, 281 yds, 2 td, 1 int, 109.9 rating
vs ind: 27-41, 278 yds, 0 td, 0 int, 85.2 rating
TOT: 219-329 (66.6%), 2,728 yds, 21 td, 6 int, 105.8 rating
So yeah, he's tremendous at home (everywhere, really). When looking for a weakness, nothing really sticks out. He can make every throw. He can throw from the pocket. He can throw on the run. He can go through progressions, and he can improvise. He can run and is a great athlete, but he doesn't take crazy risks with his legs (i.e., he's not run happy - he's first and foremost a passer). He attacks both zone and man defenses. PFF graded Mahomes as the best QB in the NFL under pressure, especially on third down.
So where's the weakness? Well, there isn't really one. Part of it is Mahomes is just a generational talent. But part of it is the quality of his skill players. Hill is phenomenal. Kelce is a great receiver. And even without Kareem Hunt, they still have lots of talent in the backfield, with Damien Williams stepping in and averaging 5.1 yards per carry (a half yard more than Hunt!). Plus they have Sammy Watkins, who's pretty good too.
In their four losses, here were the scores:
L, 43-40 at NE
L, 54-51 at LAR
L, 29-28 vs LAC
L, 38-31 at Sea
So in their losses, they're still averaging 37.5 points a game. Unreal. But in their four losses, they're giving up 41.0 points a game. So you seemingly HAVE to just roll their pretty bad defense to have a chance.
One thing that's interesting to note is that in Mahomes' four worst passing games (by passer rating...admittedly not always a totally accurate measure of a QB's performance in any given game), they were all among his top 8 games with the most passes.
So perhaps taking away the run and making Mahomes throw - despite him being a GREAT passer - is actually the way to making him perform worse, as he is prone to make a few mistakes.