I don't think that's a fair comparison. I don't know how NFL schedules work, but after week 2 teams will have played 1/16th of their possible opponents. At this point in the baseball seasons, teams have played 6 (mostly) different teams, or 1/5th of their possible opponents. While the percentage of the overall season may be the same, the sample size of games and opponents is not.At this point of the season it's akin to accessing the toughest schedule played to date when you're 2 games into a 16 game NFL schedule. Can you do it? Sure. Does it mean anything with nearly 90% of the schedule remaining, not really.
Again, I'd argue that strength of schedule is more meaningful at this point in the season simply because team experience tends to get more homogeneous over the course of the season. The next month or so is where you will see a combination of significant differences in strength of schedule with enough games played to make it at least a little bit meaningful.