Just to add to what Traut said, Topps base seems to have a really high initial Ebay sales point and then it drops quick to a longer term point. If you go that way and you're looking at something that isn't crazy limited (like low numbered) or that you don't need right now, maybe hold off until people get their claws into retail and open more of their boxes. Series 2 has only been out a monthish and is just hitting retail up here and the various inserts I'm looking at are probably at 50-60% of their earliest price.
But yeah, like the /10 ASG Manufactured Relic Auto at $300 for a sticker vs. similarly limited Topps Museum or Luminaries autos on Ebay for 70% of that price seems to tell me that you can wait on that if it's a must have...I could be wrong but it doesn't align. Looking at the other $300 sold Pedro autos you're looking at PSA10 Graded Rookies that were hand signed, dual signatures with other great names, getting close to Dynasty patch/signature combos, Even the 1/1 Diamond Icons Pedro auto from last year went for 260. I dunno, real hard to justify unless it drops a lot or you get lucky from a pack.
And yeah, the shame is with a bit more effort that card would've been a real gem, now you kind of hope you find an ideal sticker which...for a /10 you don't have the luxury of, especially with both stickers not being great (Ebay has the 7/10 and 9/10 posted). It's kinda wild that 25 years ago Leaf was able to manage a product (at $10 a pack) with a guaranteed, on-card auto with a list of 250+ active baseball players on the signing list and now it's not possible to get a /10 auto in a flagship product to be on card. I'm not wholly opposed to stickers - sometimes they are a necessity and sometimes honestly it's not worth the resources to track down a player to sign 2000 cards produced in hand. But a /10 auto of a Hall of Famer in your biggest production run product? Nevermind the Wander 1/1 that was a sticker...