As much as I am a proponent of the philosophy of not spending up on RBs in either money or draft capital,* the league is simply much more exciting when there are elite game-breaking RBs throughout the league and it's great when picks like that turn into a Saquon or Breece-level player and not a Trent Richardson (or even a merely decent RB like Sony).
*To be fair to the Jets, Breece was a 2nd rounder but their fourth pick of the draft to that point so I have little issue with them going after a guy they liked there.
Injuries are a constant cloud over this league and it really sucks but until we evolve to have more flexible ligaments there's not really anything to do except keep getting better at treating injuries.
To be fair, in the NBA last year the top 30 players missed like 35% of the season cumulatively.
But, yes, it's tough. If you watch an NFL Sunday at a sports book, you see so many guys down. Most of the injuries are not major but some of them are just brutal. Just yesterday, Mike Williams, Breece Lightning, JC Jackson, and Amon St. Brown, David Njoku, and DK Metcalf were hurt.
That is just off the top of my head, there are obviously many more.