A few quick thoughts after catching up with most of this thread:
Offense
I am strongly on the side of RedOctober that the offense needs to really commit to the run and attempt to impose our will there, mainly because of the weakness of our red zone passing offense without Gronk. The most amazing thing about the Indy game was that we hardly needed to throw in the ball in the red zone at all. We had 1st downs at the 2, 7, 12, 5, and 3 on our five red zone possessions and we threw the ball once. I can't see us winning this game without being efficient in the red zone and I think our best chance of doing that is if we can win in the running game.
If Denver sells out to stop the run, then hit them with play action and misdirection. But I really hope McDaniels doesn't out think himself, get too caught up in the chess match aspect of things, and go air-heavy. At some level, we have to just to line up and stay, "We're going to make this a physical war at the LoS and lets see if you can hold up."
Defense
I haven't felt this good about our defense against a Peyton Manning offense since 2004. Nobody is going to stop that Denver offense completely but, with the secondary finally healthy and Collins' emergence, we really have the players to match up in coverage, maybe more than any other team in the league except Seattle. The key against Peyton is always to have a good disguise, to keep changing up coverages, and to limit the damage downfield. I think we're well equipped to do that. We can keep alternating whether Hightower, Collins, or neither rushes. We can drop Nink or even Jones into coverage on occasion (as we did a few times against Indy). We can alternate man and zone and hybrid coverages. Two interesting personnel decisions are at nickel and safety. Arrington got benched for Ryan near the end of the first half against Indy and didn't see the field again. I like Ryan better as a coverage player overall but Arrington's familiarity with Welker might get him the nod. I'm also interested to see what BB does at safety - Steve Gregory played the whole game against Indianapolis, except for a few snaps that went to Tavon Wilson, but I could see Duron Harmon getting more run against Denver.
Coaching
Aside from what has already been covered, I just hope that BB is aggressive and unafraid to make some high variance calls, especially if we fall behind. If we're down multiple scores at any point then I think we need to be very aggressive on 4th down in the middle of the field. And I wouldn't mind seeing some kind of trickeration - fake punt, onside kick, etc - if the moment seems right. I see this as a game where every possession will be precious and buying one extra possession in this way could easily be the difference between having a shot at stealing a close win versus being down two scores in the 4th quarter.