All times ET. Lines from ESPN. Not all games listed.
Friday, September 16
7:30 PM Florida State (-2) at Louisville ESPN
8:00 PM Air Force (-17) at Wyoming CBSSN
Saturday, September 17
11:00 AM Wofford at Virginia Tech ACCN
12:00 PM #6 Oklahoma (-11.5) at Nebraska FOX
12:00 PM UConn at #4 Michigan (-46) ABC
12:00 PM #1 Georgia (-24.5) at South Carolina ESPN
12:00 PM Purdue at Syracuse (even) ESPN2
12:00 PM Texas State at #17 Baylor (-30.5) FS1
12:00 PM Youngstown State at #9 Kentucky SECN
2:30 PM California at Notre Dame (-10.5) NBC/Peacock
3:30 PM #12 BYU at #25 Oregon (-3.5) FOX
3:30 PM #22 Penn State (-3) at Auburn CBS
3:30 PM #20 Ole Miss (-16) at Georgia Tech ABC
3:30 PM Colorado at Minnesota (-27.5) ESPN2
3:30 PM Stony Brook at UMass ESPN3
4:00 PM UT Martin at Boise State FS1
4:00 PM ULM at #2 Alabama (-49) SECN
5:00 PM Liberty at #19 Wake Forest (-16.5) ACCN
6:00 PM Mississippi State (-2) at LSU ESPN
7:00 PM Toledo at #3 Ohio State (-31.5) FOX
7:00 PM Texas Tech at #16 NC State (-10.5) ESPN2
7:00 PM UAPB at #8 Oklahoma State ESPN+
7:00 PM Missouri State at #10 Arkansas SECN+/ESPN+
7:00 PM Akron at #24 Tennessee (-47.5) SECN+/ESPN+
7:30 PM #11 Michigan State at Washington (-3.5) ABC
7:30 PM SMU at Maryland (-3.5) FS1
7:30 PM #23 Pitt (-10) at Western Michigan ESPNU
7:30 PM USF at #18 Florida (-24.5) SECN
7:30 PM Maine at Boston College RSN/ESPN3
8:00 PM Louisiana Tech at #5 Clemson (-34) ACCN
8:00 PM UTSA at #21 Texas (-11) LHN
9:00 PM #13 Miami at #24 Texas A&M (-5.5) ESPN
10:00 PM San Diego State at #14 Utah (-21) ESPN2
10:30 PM Fresno State at #7 USC (-12.5) FOX
11:00 PM North Dakota State at Arizona FS1
Friday, September 16
7:30 PM Florida State (-2) at Louisville ESPN
8:00 PM Air Force (-17) at Wyoming CBSSN
Saturday, September 17
11:00 AM Wofford at Virginia Tech ACCN
12:00 PM #6 Oklahoma (-11.5) at Nebraska FOX
12:00 PM UConn at #4 Michigan (-46) ABC
12:00 PM #1 Georgia (-24.5) at South Carolina ESPN
12:00 PM Purdue at Syracuse (even) ESPN2
12:00 PM Texas State at #17 Baylor (-30.5) FS1
12:00 PM Youngstown State at #9 Kentucky SECN
2:30 PM California at Notre Dame (-10.5) NBC/Peacock
3:30 PM #12 BYU at #25 Oregon (-3.5) FOX
3:30 PM #22 Penn State (-3) at Auburn CBS
3:30 PM #20 Ole Miss (-16) at Georgia Tech ABC
3:30 PM Colorado at Minnesota (-27.5) ESPN2
3:30 PM Stony Brook at UMass ESPN3
4:00 PM UT Martin at Boise State FS1
4:00 PM ULM at #2 Alabama (-49) SECN
5:00 PM Liberty at #19 Wake Forest (-16.5) ACCN
6:00 PM Mississippi State (-2) at LSU ESPN
7:00 PM Toledo at #3 Ohio State (-31.5) FOX
7:00 PM Texas Tech at #16 NC State (-10.5) ESPN2
7:00 PM UAPB at #8 Oklahoma State ESPN+
7:00 PM Missouri State at #10 Arkansas SECN+/ESPN+
7:00 PM Akron at #24 Tennessee (-47.5) SECN+/ESPN+
7:30 PM #11 Michigan State at Washington (-3.5) ABC
7:30 PM SMU at Maryland (-3.5) FS1
7:30 PM #23 Pitt (-10) at Western Michigan ESPNU
7:30 PM USF at #18 Florida (-24.5) SECN
7:30 PM Maine at Boston College RSN/ESPN3
8:00 PM Louisiana Tech at #5 Clemson (-34) ACCN
8:00 PM UTSA at #21 Texas (-11) LHN
9:00 PM #13 Miami at #24 Texas A&M (-5.5) ESPN
10:00 PM San Diego State at #14 Utah (-21) ESPN2
10:30 PM Fresno State at #7 USC (-12.5) FOX
11:00 PM North Dakota State at Arizona FS1