While injury risk is not the same, if you go into a season assuming your tackles are going to play 17 you're going to be disappointed,
Here are the teams who had at least 1 tackle start 17 games last year: Bills (both did), Bengals (both did), Jags (1 of 2), Chiefs (1 of 2), Broncos (1 of 2), Chargers (both), Cardinals (1 of 2), 49ers (1 of 2), Panthers (both), Falcons (1of2), Bucs (both), Bears (1 of 2), Lions (1 of 2), Commanders (1 of 2), Eagles (1 of 2), COwboys (1of 2)
So half the league had neither tackle start every game, and only 5/32 had BOTH tackles start every game.
You should go into every season assuming your tackles are going to miss some games. Jonah Williams is on the market, he just started 17.... he's unlikely to start all 17 next year and you shouldn't assume it.
Tyron Smith is really good, like top 5 in the league type of good when he plays. I'd much rather roll the dice on elite talent than reduce my injury risk for lesser talent. You need a 3rd tackle either way (though in this case, they have McDermott/Anderson, which with a rookie is fine for the 3-5 spots.)