The problem with these Azzuri is that the central trio - Bonucci, Chiellini, & Jorginho - are slow, slower, and slowest. Teams with speed up top will exploit that by targeting the space behind the FBs, and putting those 3 into some foot races.
Obviously, those are also 3 really really intelligent players, so they know how to position themselves well, and Locatelli can cover ground and break up play very well. Mancini can also keep the FBs at home, but that blunts the attack and will turn things into more classic Italian approach. That makes them a hard out even if they are outmatched.