The offense hasn't played well in a month, they're going to get snaps. Once Brady gets snaps, you are sort of locked into the OL (and to a lesser extent Gronk) getting snaps so I think its going to be all starters go for a half, at least on offense.
Defense is a little bit of a different beast, I think there's a pretty good argument to sit Revis and let Dennard get a full game in at the outside or at the very least make Revis the first guy off the field. Similarly, sitting McCourty and letting Harmon play seems fine to me.
Edelman, Connolly, Blount, and Arrington probably get the week off. Some of the other guys who have been dinged to a lesser extent (LaFell, Gray, Hightower, Chandler Jones, Chung via Reiss speculation) might get the week off or reduced snaps depending on how they feel. I expect a liberal substitution pattern for the big guys up front.
I almost don't want to watch because Im basically just going to be holding my breath for Gronk and Brady and Revis the whole game even though I understand why they are going to play some. Will be much more fun in the second half when its Jimmy G launching bombs to Tyms like its mid August.