Management is pretty transferable, and while the sports are different managing athletes is somewhat similar across sports. Building and administering an organization is also pretty transferable. So at some level, I get this. Stan Kasten oversaw teams in different sports effectively, because he was a very good manager; there are other examples if we broaden the aperture a bit. But it's hardly easy to execute, and very much depends on the skill of the individual
One question is how good DePo actually was at either of those things. He failed with the Dodgers, and we have almost no visibility into his success with the Mets (at least, that I am aware of). So, while in theory bringing on an experienced sports exec who can build an organization, implement an anlytics culture, and manage high performers makes sense---I don't know that there's much reason to think they got that guy. If they (say) hired Gregg Popovich I'd find it easier to get why you'd think it might work---he actually has those skills, very clearly.
The second part is that those transferable skills require subject matter experts when they cross industries/segments/organizations. And right now, the Browns don't have them. Of course, if you trust the people who are building things you believe they'll find them, and that's what we'll have to watch for. But it's an essential ingredient and not currently in place, and I suspect will be harder to attract them given the counter-traditional front office and the questionable history in place.