I agree. Personally 2006 always stands out as the year the Sox just couldn't catch a break and injuries destroyed the season. On August 16th the Sox were 69-50, 1.5 games behind the Yankees with the 4th best record in the AL. But Varitek, Manny, Coco, Papelbon, Lester, Clement, and Foulke all missed significant time throughout the season, and it felt like it culminated in the 5 game sweep by the Yankees at Fenway in late August. They finished 17-26 and missed the playoffs.
Tried to look this up for some context, according to one measure by Sportrac:
https://www.spotrac.com/mlb/disabled-list/cumulative-team/
Obviously this is a pretty blunt tool -- it's hard to account for the quality of the players on IL (Arroyo missing time isn't the same as Chris Sale missing time, etc.). The way they try to account for that is by "salary accrued on IL."
So the Sox are 7th in total "days missed by players on IL" in 2022 at 1,271, but 1st in MLB in "money spent on IL players" at $47M. If you click on the numbers it shows you who counts and why (NB they seem to have an error -- Strahm is listed as having been on the IL for 300+ days which isn't correct).
For context, the list only goes back to 2015, but in those years here's where the Sox ranked by "days missed by players on IL":
2021: 29th
2020: 12th
2019: 7th
2018: 11th
2017: 5th
2016: 10th
2015: 15th